Sulfobutylether-β-Cyclodextrin(SBE-β-CD) is a kind of sodium salt which is alkylated by beta cyclodextrin with 1,4-butanesulfonic acid lactone under alkaline condition. It is a anion and high water-soluble beta cyclodextrin derivative.
Sulfobutylether-β-Cyclodextrin (SBE-β-CD) can form a non covalent complex with drug molecules, which can improve the stability, water solubility and safety of drugs, reduce renal toxicity, alleviate the hemolysis of drugs, control the release rate of drugs, cover up bad smell, etc.
Compared with betacyl dextrin, it has better water solubility and lower hemolytic effect, so it is a new kind of pharmaceutical excipient with very broad application prospect.