For a long time, the deposition of Aβis the main cause of degeneration and death of neurons around the senile plaques in AD patients. The deposition of Aβis not only related to the degeneration of neurons, but also can activate a series of pathological events, including the activation of astrocytes and microglia, the breaking of blood-brain barrier and the change of microcirculation.
The study of Amyloid β-Protein (3-42), which can remove the first and second amino acids at the N-terminal, is more detailed, which is helpful for human to conquer Alzheimer's disease.
In the solid-phase synthesis method, there is the same sequence between the Amyloid β-Protein (3-42) and the amino Amyloid β-Protein (1-42).The overall process is basically the same, but there are differences in purification.