Characteristics
1. Solubilization
Neutral, positive and negative APIs can effectively combine with sulfobutyl-β- cyclodextrin, which can increase the solubility of
compounds with different solubility by 10 to 25000 times.
2. Convenient administration:
Sulfobutyl-β-cyclodextrin has good biocompatibility and can be administered by injection, oral administration,eye,nose, external
use and inhalation.
3. Good safety:
Usually, Sulfobutyl-β-cyclodextrincan be quickly and completely eliminated from the kidney after administration. In vitro and in
vivo acute, subacute and chronic toxicity studies provide safe data and are approved for use in human drug preparations.
4. Good stability:
The interaction with sulfobutyl-β- cyclodextrin provides a beneficial protective environment for API in its lipophilic cavity, while
the hydrophilic surface provides excellent water solubility, solubility and stability.
〡Applications:
Sulfobutylether-β- cyclodextrin is a new type of anionic high soluble cyclodextrin derivatives. It could embed drug molecules to
form covalent compounds to increase the drug’s stability,solubility,safety.It could reduce the renal toxicity,moderate drug’s
hemolysis, control the release rate and cover up the bad smell.
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